Thoughts on best grid for use with a cms

I am updating an old theme for a cms and was wondering what peoples thoughts are on the best grid system to use. Because its a cms with lots of 3rd party packages (like all cms) there is no nice way to resize everything from my understanding. I am not in any way new to css but have coded everything custom up until now and its my first trip into grids. I have read a lot of documentation this week but would like to know what others think works best.

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